Type I Collagen-Based Devices to Treat Nerve Injuries after Oral Surgery Procedures. A Systematic Review

doi:10.3390/app11093927

★ Alto impactoQ1 · EngineeringImpact Factor · 3.618

AutoresAndrea Roccuzzo, Pedro Molinero‐Mourelle, Martina Ferrillo, Carlos Cobo-Vázquez, Luis Sánchez‐Labrador, Antonio Ammendolia, Mario Migliario, Alessandro de Sire

Por qué importa

Este estudio revisa sistemáticamente la evidencia sobre el uso de dispositivos a base de colágeno tipo I para tratar lesiones nerviosas que pueden ocurrir tras procedimientos de cirugía oral, como la extracción de muelas del juicio, afectando al nervio dentario inferior o lingual. Aunque las opciones de tratamiento son variadas y no existe un consenso claro sobre el estándar de oro, la neurorrafia directa sin tensión utilizando estos dispositivos de colágeno ha ganado atención. La revisión analizó cuatro estudios, incluyendo 65 pacientes, y encontró resultados clínicos positivos en términos de mejora sensorial a partir de los tres meses postoperatorios. Sin embargo, el nivel de evidencia general se considera bajo, lo que subraya la necesidad de ensayos clínicos comparativos con mayor número de participantes para confirmar estos prometedores hallazgos y optimizar la práctica clínica.

Abstract original

The regeneration of nerve injuries after oral surgery procedures is a quite often attempted procedure in dental medicine. Despite several proposed technical approaches, there is still a lack of consensus on which should be considered the gold standard procedure, even-though in the last decades, the use of collagen-based devices allowing a tension-free direct neurorrhaphy has been used. A systematic search of multiple electronic databases and hand searching was conducted to assess the level of evidence behind the use of type I collagen devices to treat nerve injuries after oral surgery procedures. After screening, four articles (one case series and three retrospective studies) including overall 65 patients suffering from inferior alveolar (IAN)/lingual nerve (LN) injury after mandibular wisdom tooth extraction, met the inclusion criteria and could be included. The Oxford Centre for evidence-based medicine (OCEBM) scaling system was used to evaluate the quality of the included studies. Positive clinical results in terms of sensorial improvements were recorded at least 3 months after surgery, even-though the overall level of evidence is low. The use of collagen membranes to enhance nerve regeneration in oral surgery results in promising results. Nevertheless, additional clinical comparative trials with larger sample sizes are needed.

Leer texto completo ↗DOI · 10.3390/app11093927

Autor Doctor&Cols

Carlos M. Cobo Vázquez
Cirugía Oral e Implantología

Cómo citar

Roccuzzo A, Molinero‐Mourelle P, Ferrillo M, Cobo-Vázquez C, Sánchez‐Labrador L, Ammendolia A, et al. Type I Collagen-Based Devices to Treat Nerve Injuries after Oral Surgery Procedures. A Systematic Review. Applied Sciences. 2021. doi:10.3390/app11093927