Application of local melatonin for controlling peri-implantitis: a randomized clinical trial

doi:10.21203/rs.3.rs-7095643/v1

AutoresCarlos Cobo-Vázquez, Pedro Molinero‐Mourelle, Cristina Madrigal-Martínez-Pereda, Luis Sánchez‐Labrador, Cristina Méniz-García, José María Martínez González, Juan López-Quiles

Por qué importa

Se ha evaluado la aplicación local de melatonina como coadyuvante en el tratamiento de la periimplantitis, una condición inflamatoria que afecta a los tejidos que rodean los implantes dentales. El estudio, un ensayo clínico aleatorizado, buscó determinar si la melatonina, conocida por sus propiedades antiinflamatorias y antimicrobianas, podría mejorar parámetros clínicos como la profundidad de sondaje, el sangrado y el nivel óseo periimplantario, además de su efecto sobre ciertos patógenos bacterianos. Aunque los resultados no mostraron diferencias significativas en la mayoría de los parámetros medidos frente al placebo, se observó una leve tendencia a la mejora en la reducción de la profundidad de sondaje y en la concentración de P. gingivalis en el grupo tratado con melatonina. Estos hallazgos sugieren un potencial limitado pero interesante a corto plazo para esta molécula en el manejo de la periimplantitis, mereciendo consideraciones futuras.

Abstract original

Objectives : The main objective was to determine the effectiveness of melatonin in the treatment of peri-implantitis. Secondary objectives were to determine the anti-inflammatory, osteogenic and antimicrobial properties of melatonin. Materials and Methods : A randomized clinical trial was carried out in patients affected by peri-implantitis with a follow-up of 60 days. Melatonin 1.9 mg or placebo was applied locally to the peri-implant defect after debridement. The probing depth, bleeding index, plaque index, and interleukin-1β and 6 concentrations, peri-implant bone level and the bacterial strains were analyzed. Results : 30 patients were analyzed with a mean age of 71.9±7.3 years. Changes on the probing depth in the melatonin group were -1.80±0.88 mm and -1.38±0.47 mm in placebo. Bone level changes were -0.87±0.74 mm in the melatonin group and -0.80±0.68 mm in the placebo. The interleukin-1β concentration at 60 days was 8.62±5.09 pg/mL in the melatonin group and 9.07±5.57 pg/mL in placebo. No differences were observed in probing depth (p=.17), plaque index (p=.57), bleeding index (p=.91), peri-implant bone level (p=.43), interleukin-1β (p=.80), interleukin-6 (p=.52) and anaerobic bacterial species (p=0.96). There were differences in the P. gingivalis concentration (p=.05). Conclusions : Anti-inflammatory, analgesic, osteogenic and antimicrobial properties of melatonin cannot be determined. It seems to improve slightly probing depth changes, interleukin-1β levels and P. gingivalis concentration. Trial registration : Protocol Registration & Results System Clinical Trial Number NCT06816277- Clinical Relevance: Melatonin could improve plaque index, bleeding index, reduce probing depth and peri-implant marginal bone loss, in addition to controlling certain bacterial species in the short term.

Leer texto completo ↗DOI · 10.21203/rs.3.rs-7095643/v1

Autor Doctor&Cols

Carlos M. Cobo Vázquez
Cirugía Oral e Implantología

Cómo citar

Cobo-Vázquez C, Molinero‐Mourelle P, Madrigal-Martínez-Pereda C, Sánchez‐Labrador L, Méniz-García C, González JMM, et al. Application of local melatonin for controlling peri-implantitis: a randomized clinical trial. Research Square. 2025. doi:10.21203/rs.3.rs-7095643/v1