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Ata-Ali F, Ata-Ali J, Flichy-Fernández AJ, Bagan JV. Osteonecrosis of the jaws in patients treated with bisphosphonates. Journal of Clinical and Experimental Dentistry. 2012. doi:10.4317/jced.50649
AutoresFadi Ata-Ali, Javier Ata-Ali, Antonio J Flichy-Fernández, José V Bagan
Esta revisión bibliográfica aborda la osteonecrosis de los maxilares (ONJ) inducida por bifosfonatos, una complicación cada vez más frecuente en pacientes que reciben esta terapia. Se caracteriza por la exposición de hueso necrótico en la región maxilofacial durante más de ocho semanas, sin radioterapia previa. El estudio examina su etiopatogenia, factores de riesgo, manifestaciones clínicas, diagnóstico, tratamiento y estrategias de prevención. Es crucial que tanto el médico prescriptor como el cirujano dentista informen al paciente sobre este riesgo, obteniendo el consentimiento informado. Dada la creciente incidencia y el impacto en la calidad de vida del paciente, la comprensión de esta patología resulta fundamental para la práctica clínica.
The literature describes an increasing presence of bisphosphonate-induced osteonecrosis of the jaws (ONJ), characterized by the exposure for over 8 weeks of necrotic bone in the maxillofacial region, after bisphosphonate therapy, in the absence of prior maxillary radiotherapy. The present literature review examines the etiopathogenesis, risk factors, clinical forms, diagnosis, treatment and prevention of bisphosphonate-induced ONJ. In addition, a review is made of all the series involving over 15 patients diagnosed with this disorder between 1 January 2011 and 15 May 2011. A PubMed-Medline search was carried out with the following key words: “bisphosphonates” and “osteonecrosis”. The appearance of osteonecrosis is a serious complication, with an increasing incidence, that affects patient quality of life and causes important morbidity. All patients treated with bisphosphonates are at risk of developing osteonecrosis as a result of such medication. This potential complication therefore should be explained to the patient by both the prescribing physician and the dental surgeon in charge of oral treatment, with the obtainment of informed consent in all cases.
Ata-Ali F, Ata-Ali J, Flichy-Fernández AJ, Bagan JV. Osteonecrosis of the jaws in patients treated with bisphosphonates. Journal of Clinical and Experimental Dentistry. 2012. doi:10.4317/jced.50649
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