Effect of Applying 1% Metformin on Guided Bone Regeneration Processes with Bovine-Derived Xenografts

doi:10.3390/jcm13102973

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AutoresOier Montalbán-Vadillo, Esteban Pérez-Pevida, Iratxe Viteri-Agustín, David Chávarri-Prado, Alejandro Estrada-Martínez, Markel Diéguez-Pereira, Fernando Sánchez-Lasheras, Aritza Brizuela-Velasco

Por qué importa

Este estudio investiga el impacto de la aplicación tópica de una solución de metformina al 1% en la regeneración ósea guiada utilizando injertos xenogénicos de origen bovino. Los resultados preliminares en un modelo animal sugieren un incremento en la neoformación ósea y una mejor integración del biomaterial. Dada la creciente utilización de xenoinjertos en procedimientos de regeneración ósea y la búsqueda de coadyuvantes que mejoren la osteogénesis, esta investigación podría ofrecer información relevante para optimizar los resultados clínicos en la regeneración de defectos óseos, especialmente en el ámbito de la implantología y la cirugía maxilofacial.

Abstract original

Background: Although xenografts have shown successful results in GBR procedures due to their osteoconductive properties, many authors have opted to add co-adjuvant drugs to favor osteogenesis and differentiate cells into an osteoblastic lineage. Metformin has been shown to have bone-protective properties, regulating osteoclast differentiation, as well as the ability to promote osteoblast mineralization and differentiation. The present study aimed to evaluate the effect of the local application of a 1% metformin solution on bone neoformation in the treatment of an experimental bone defect in a guided bone regeneration animal model with a particulated bovine hydroxyapatite xenograft with hyaluronate. Methods: With this purpose in mind, two critical defects with 8 mm diameter and 0.5 mm depth were created in eight male New Zealand rabbit calvarias. Titanium cylinders were fixed in each defect and filled with particulate hydroxyapatite of bovine origin and sodium hyaluronate, with sterile injectable saline added to the control group and sterile 1% metformin solution added to the test group. At 6 weeks, the animals were euthanized, and samples were obtained and prepared for histomorphometric analysis. Results: A higher percentage of new bone formation was observed in the metformin samples than in the control samples, both in the region closest to the animal's calvaria and in the most distal region analyzed. A higher average bone–biomaterial contact percentage was observed in the samples, with metformin in both the proximal and distal regions. There was no statistically significant difference in the mean value in either region in both parameters. Conclusion: The local application of a 1% metformin solution in an animal model of guided bone regeneration with particulate bovine hydroxyapatite and hyaluronate resulted in greater bone neoformation and xenograft osseointegration than in the control group.

Leer texto completo ↗DOI · 10.3390/jcm13102973

Autores Doctor&Cols

Cómo citar

Montalbán-Vadillo O, Pérez-Pevida E, Viteri-Agustín I, Chávarri-Prado D, Estrada-Martínez A, Diéguez-Pereira M, et al. Effect of Applying 1% Metformin on Guided Bone Regeneration Processes with Bovine-Derived Xenografts. Journal of Clinical Medicine. 2024. doi:10.3390/jcm13102973