The Impact of Compaction Force on Graft Consolidation in a Guided Bone Regeneration Model

doi:10.11607/jomi.8082

Q2 · DentistryImpact Factor · 2.056

AutoresViteri-Agustín I, Brizuela-Velasco A, Lou-Bonafonte JM, Jiménez-Garrudo A, Chávarri-Prado D, Pérez-Pevida E, Benito-Garzón L, Gruber R

Por qué importa

Este estudio evalúa la influencia de dos fuerzas de compresión distintas (0.7 y 1.6 kg/cm2) sobre la consolidación de hidroxiapatita bovina particulada en un modelo de regeneración ósea guiada en conejos. Se investigó el efecto de estas fuerzas en la formación de hueso nuevo y el contacto hueso-biomaterial en áreas adyacentes al hueso del cráneo y a la membrana de colágeno, así como la vascularización. Aunque se observaron ligeras diferencias numéricas en los parámetros histomorfométricos estudiados entre ambos grupos de compresión, estas no resultaron estadísticamente significativas. La conclusión principal indica que ambas fuerzas de compresión aplicadas, dentro del rango evaluado, producen resultados de consolidación similares en el biomaterial empleado, sugiriendo que la fuerza de compactación manual, a pesar de su variabilidad, podría no ser un factor crítico determinante en la eficacia de la regeneración ósea guiada en este tipo de modelos.

Abstract original

Purpose: Compaction of particulated grafts is done manually; thus, the effect of compression force on bone regeneration remains unclear. The aim of this study was to evaluate the impact of two different compression forces on the consolidation of particulated bovine hydroxyapatite. Materials and Methods: Two titanium cylinders were fixed on the calvarium of eight New Zealand rabbits. Both defects were filled with particulated bovine hydroxyapatite subjected to a compression force of 0.7 kg/cm2 or 1.6 kg/cm2 before being covered with a resorbable collagen membrane. A handheld device that uses a spring to control the compression force applied by the plugger was used. At 6 weeks, histomorphometry of the area immediately adjacent to the calvaria bone and to the collagen membrane was performed. Results: It was shown that next to the calvaria, the bone volume per tissue volume (BV/TV) was 29.0% ± 8.8% and 27.6% ± 8.2% at low and high compression force, respectively; the bone-to-biomaterial contact (BBC) was 58.2% ± 25.0% and 69.3% ± 22.9%, respectively (P > .05). In the corresponding area next to the collagen membrane, BV/TV was 4.9% ± 5.1% and 5.7% ± 4.7%, and the BBC was 18.3% ± 20.8% and 20.1% ± 15.9%, respectively (P > .05). In addition, the number and area of blood vessels were not significantly affected by compression force. Conclusion: Both compression forces applied resulted in similar consolidation of bovine hydroxyapatite expressed by new bone formation and vascularization based on a rabbit calvaria augmentation model.

Leer texto completo ↗DOI · 10.11607/jomi.8082

Autores Doctor&Cols

Cómo citar

Viteri-Agustín I, Brizuela-Velasco A, Lou-Bonafonte JM, Jiménez-Garrudo A, Chávarri-Prado D, Pérez-Pevida E, et al. The Impact of Compaction Force on Graft Consolidation in a Guided Bone Regeneration Model. The International Journal of Oral & Maxillofacial Implants. 2020. doi:10.11607/jomi.8082