Understanding Solid-Based Platelet-Rich Fibrin Matrices in Oral and Maxillofacial Surgery: An Integrative Review of the Critical Protocol Factors and Their Influence on the Final Product

doi:10.3390/medicina59111903

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AutoresÁngel-Orión Salgado-Peralvo, Naresh Kewalramani, Alba Pérez-Jardón, Jesús Pato-Mourelo, et al.

Por qué importa

Este artículo aborda los factores críticos en la preparación de matrices de fibrina rica en plaquetas (PRF) sólidas, un concentrado plaquetario de segunda generación ampliamente utilizado en cirugía oral y maxilofacial. La revisión integrativa analiza cómo variables como el tipo de tubo de extracción, la duración de la flebotomía, los parámetros de centrifugación, el tiempo hasta la deshidratación y el uso clínico, influyen en las características macroscópicas y microscópicas del producto final. Comprender estas variables es esencial para los clínicos, ya que permite optimizar la producción de PRF mediante la combinación de protocolos y materiales, mejorando potencialmente los resultados en procedimientos regenerativos y quirúrgicos.

Abstract original

Platelet-rich fibrin (PRF) is a second-generation platelet concentrate whose use in clinical practice has been widely disseminated. This has led to the development of several commercial protocols, creating great confusion as to the terminology and implications of each of them. This integrative review aims to identify the critical factors of each of the phases of the solid-based PRF matrix protocol and their possible influence on their macro- and microscopic characteristics. An electronic search of the MEDLINE database (via PubMed), Web of Science, Scopus, LILACS, and OpenGrey was carried out. The search was temporarily restricted from 2001 to 2022. After searching, 43 studies were included that met the established criteria. There were numerous factors to consider in the PRF protocol, such as the material of the blood collection tubes, the duration of phlebotomy, the parameters related to blood centrifugation, the time from centrifugation to dehydration of the fibrin clots and their dehydration into membranes, as well as the time to clinical use. These factors influenced the macro- and microscopic characteristics of the PRF and its physical properties, so knowledge of these factors allows for the production of optimised PRF by combining the protocols and materials.

Leer texto completo ↗DOI · 10.3390/medicina59111903

Autores Doctor&Cols

Cómo citar

Salgado-Peralvo Á, Kewalramani N, Pérez-Jardón A, Pato-Mourelo J, al. E. Understanding Solid-Based Platelet-Rich Fibrin Matrices in Oral and Maxillofacial Surgery: An Integrative Review of the Critical Protocol Factors and Their Influence on the Final Product. Medicina. 2023. doi:10.3390/medicina59111903