Osteoblastic and Bacterial Response of Hybrid Dental Implants

doi:10.3390/jfb14060321

★ Alto impactoQ1 · EngineeringImpact Factor · 5.284

AutoresDaniel Robles, Aritza Brizuela‐Velasco, Manuel Fernández‐Domínguez, Javier Gil

Por qué importa

Este estudio investiga la respuesta osteoblástica y bacteriana de implantes dentales híbridos, que combinan áreas lisas y rugosas en su superficie. Se evaluó cómo la rugosidad, la mojabilidad y la energía superficial de diferentes tratamientos (liso, liso-rugoso y completamente rugoso) influyen en la adhesión, proliferación y diferenciación de osteoblastos humanos, así como en la colonización por bacterias orales comunes. Comprender estas interacciones es crucial para mejorar la integración de los implantes y prevenir la periimplantitis, una complicación que puede llevar a la pérdida ósea y al fracaso del implante. Los resultados sugieren que las superficies rugosas promueven una mayor actividad celular osteogénica, lo cual es relevante para optimizar el diseño de implantes y mejorar los resultados clínicos a largo plazo en la implantología.

Abstract original

Bacterial infections in dental implants generate peri-implantitis disease that causes bone loss and the mobility of the dental implant. It is well known that specific ranges of roughness favor the proliferation of bacteria, and it is for this reason that new dental implants called hybrids have appeared. These implants have a smooth area in the coronal part and a rough surface in the apical part. The objective of this research is the physico-chemical characterization of the surface and the osteoblastic and microbiological behavior. One-hundred and eighty discs of titanium grade 3 with three different surfaces (smooth, smooth–rough, and completely rough) were studied. The roughness was determined by white light interferometry, and the wettability and surface energy by the sessile drop technique and the application of Owens and Wendt equations. Human osteoblast SaOS-2 was cultured to determine cell adhesion, proliferation, and differentiation. Microbiological studies were performed with two common bacterial strains in oral infection, E. faecalis and S. gordonii, at different times of culture. The roughness obtained for the smooth surface was Sa = 0.23 and for the rough surface it was 1.98 μm. The contact angles were more hydrophilic for the smooth surface (61.2°) than for the rough surface (76.1°). However, the surface energy was lower for the rough surface (22.70 mJ/m2) in both its dispersive and polar components than the smooth surface (41.77 mJ/m2). Cellular activity in adhesion, proliferation, and differentiation was much higher on rough surfaces than on smooth surfaces. After 6 h of incubation, the osteoblast number in rough surfaces was more than 32% higher in relation to the smooth surface. The cell area in smooth surfaces was higher than rough surfaces. The proliferation increased and the alkaline phosphatase presented a maximum after 14 days, with the mineral content of the cells being higher in rough surfaces. In addition, the rough surfaces showed greater ba

Leer texto completo ↗DOI · 10.3390/jfb14060321

Autor Doctor&Cols

Daniel Robles Cantero
Cirugía Oral e Implantología

Cómo citar

Robles D, Brizuela‐Velasco A, Fernández‐Domínguez M, Gil J. Osteoblastic and Bacterial Response of Hybrid Dental Implants. Journal of Functional Biomaterials. 2023. doi:10.3390/jfb14060321

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Osteoblastic and Bacterial Response of Hybrid Dental Implants