Granulomatosis with Poliangeitis (Wegener's Granulomatosis): Orofacial Manifestations. Systematic Review and Case Report.

doi:10.3290/j.ohpd.a45433

AutoresMaría Apoita-Sanz, Patricia Blanco-Jauset, Carlos Polis-Yanes, Rosa Maria Penin-Mosquera, Gallego Montserrat-Gomá, Laura Pozuelo-Arquimbau, August Vidal-Bell, Carlos Arranz-Obispo, José López‐López

Por qué importa

Se presenta una revisión sistemática y un caso clínico sobre las manifestaciones orofaciales de la Granulomatosis con Poliangeítis (GPA), anteriormente conocida como Granulomatosis de Wegener. El estudio analizó 19 casos clínicos publicados en la última década, destacando la gingiva como la zona más afectada y la hiperplasia gingival como la lesión más prevalente. Es relevante para el odontólogo reconocer que esta patología multisistémica, con potencial de morbilidad y mortalidad significativas si no se trata, puede debutar con signos orales. La identificación temprana de estas manifestaciones, como la hiperplasia gingival observada en casi el 70% de los casos como primer signo, es crucial para mejorar el pronóstico del paciente, dado que el tratamiento médico sistémico condujo a la resolución de las lesiones en la mayoría de los casos analizados.

Abstract original

PURPOSE: To present an update the orofacial manifestations of granulomatosis with polyangiitis (GPA) and present a clinical case with the initial signs in the oral cavity. MATERIALS AND METHODS: A bibliographic search was performed on Pubmed with the keywords 'Wegener's granulomatosis', 'etiology', 'oral manifestations', 'oral cavity', 'gingiva'. The inclusion criteria were papers published in English in the last 10 years that made reference to clinical cases with in which the oral cavity was affected. The quality of the results was assessed with 'The 2013 Care Checklist'. RESULTS: Nineteen clinical cases were analysed. The average quality was 7.68/13 (range 5-10/13). 73.7% of patients were women, the most frequent area for the lesions was the gingiva and the most prevalent lesion was gingival hyperplasia. 68.4% of the patients had this lesion as a first sign, 21.1% as a progression and 10.5% as a recurrence. 68.4% of the lesions resolved once medical treatment was established. CONCLUSION: GPA is a multisystem disorder associated with considerable morbidity and mortality if not treated. Early diagnosis improves the prognosis. The first manifestation of the disease can be seen in the oral cavity. It is important that dentists recognise the oral manifestation in order to improve the prognosis. Key words: granulomatosis, polyangiiitis, Wegener's granulomatosis.

Leer texto completo ↗DOI · 10.3290/j.ohpd.a45433

Autor Doctor&Cols

Carlos Polis Yanes
Cirugía Oral e Implantología

Cómo citar

Apoita-Sanz M, Blanco-Jauset P, Polis-Yanes C, Penin-Mosquera RM, Montserrat-Gomá G, Pozuelo-Arquimbau L, et al. Granulomatosis with Poliangeitis (Wegener's Granulomatosis): Orofacial Manifestations. Systematic Review and Case Report.. PubMed. 2020. doi:10.3290/j.ohpd.a45433