Effect of the Nature of the Particles Released from Bone Level Dental Implants: Physicochemical and Biological Characterization

doi:10.3390/coatings12020219

★ Alto impactoQ1 · EngineeringImpact Factor · 3.758

AutoresJuan Carlos Vara, Juan J. Delgado, Alejandro Estrada-Martínez, Esteban Pérez-Pevida, Aritza Brizuela‐Velasco, Begoña M. Bosch, Román A. Pérez, Javier Gil

Por qué importa

Este estudio analiza las partículas liberadas durante la colocación de implantes dentales de nivel óseo, comparando titanio puro grado 4 con la aleación Ti6Al4V. Se evaluaron el tamaño, morfología, liberación de iones y la respuesta celular in vitro. Los hallazgos indican que las partículas de la aleación Ti6Al4V liberan cantidades significativas de vanadio y presentan menor citocompatibilidad y mayor respuesta inflamatoria, evidenciada por marcadores como TNFα e Il-1β, en comparación con el titanio puro. Estos resultados son relevantes para comprender la posible interacción de los materiales de implantes con los tejidos circundantes y su impacto biológico, aspectos cruciales en la selección de materiales y la planificación quirúrgica en implantología.

Abstract original

The placement of bone–level dental implants can lead to the detachment of particles in the surrounding tissues due to friction with the cortical bone. In this study, 60 bone–level dental implants were placed with the same design: 30 made of commercially pure grade 4 titanium and 30 made of Ti6Al4V alloy. These implants were placed in cow ribs following the company’s placement protocols. Particles detached from the dental implants were isolated and their size and specific surface area were characterized. The irregular morphology was observed by scanning electron microscopy. Ion release to the medium was determined at different immersion times in physiological medium. Cytocompatibility studies were performed with fibroblastic and osteoblastic cells. Gene expression and cytokine release were analysed to determine the action of inflammatory cells. Particle sizes of around 15 μM were obtained in both cases. The Ti6Al4V alloy particles showed significant levels of vanadium ion release and the cytocompatibility of these particles is lower than that of commercially pure titanium. Ti6Al4V alloy presents higher levels of inflammation markers (TNFα and Il–1β) compared to that of only titanium. Therefore, there is a trend that with the alloy there is a greater toxicity and a greater pro-inflammatory response.

Leer texto completo ↗DOI · 10.3390/coatings12020219

Autores Doctor&Cols

Cómo citar

Vara JC, Delgado JJ, Estrada-Martínez A, Pérez-Pevida E, Brizuela‐Velasco A, Bosch BM, et al. Effect of the Nature of the Particles Released from Bone Level Dental Implants: Physicochemical and Biological Characterization. Coatings. 2022. doi:10.3390/coatings12020219