Algae-derived hydroxyapatite behavior as bone biomaterial in comparison with anorganic bovine bone: A split-mouth clinical, radiological, and histologic randomized study in humans

doi:10.1111/clr.13590

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AutoresPablo Galindo-Moreno, Miguel Padial-Molina, Lucia Lopez-Chaichio, Lourdes Gutiérrez-Garrido, Natividad Martín-Morales, Francisco O'Valle

Por qué importa

Este estudio compara el comportamiento de un biomaterial de origen marino, hidroxiapatita ficogénica modificada (BP), frente al hueso bovino inorgánico (ABB), ambos combinados con hueso cortical autólogo (ACB), en elevaciones de seno maxilar. El objetivo fue evaluar su eficacia como material de injerto óseo en odontólogos. Los resultados radiográficos mostraron una mayor ganancia ósea con el hueso bovino inorgánico. A nivel histológico, el material de origen marino presentó mayor cantidad de tejido no mineralizado y menor remanente de biomaterial, sugiriendo una remodelación más activa. Sin embargo, esto se asoció a una mayor reabsorción vertical y colapso del injerto. La investigación aporta información relevante para la selección de biomateriales en regeneración ósea guiada, considerando tanto la formación ósea como la estabilidad a largo plazo.

Abstract original

Objectives To analyze a modified biphasic phycogenic biomaterial in comparison with anorganic bovine bone in maxillary sinus floor elevation in humans. Material and methods Eight male patients in need of bilateral two-stage sinus floor elevation were consecutively recruited for this randomized split-mouth study. A combination of autogenous cortical bone (ACB, 20%) and anorganic bovine bone (ABB, 80%) (ACB + ABB group) or ACB (20%) and modified biphasic phycogenic material (BP, 80%) (ACB + BP group) were randomly assigned to graft each sinus. Patients were followed up for 6 months post-surgery when bone samples were collected for analysis. Results Radiographically, bone height gain was statistically higher in the ACB + ABB versus the ACB + BP group. While the analysis of the biological compartments showed differences in non-mineralized tissue (39.15 ± 20.97% vs. 65.87 ± 28.59%, ACB + ABB vs. ACB + BP respectively; p = .018) and remnant biomaterial particles (22.62 ± 17.01% vs. 7.96 ± 8.57%, respectively; p = .028), the percentage of mineralized tissue (38.23 ± 17.55% vs. 24.14 ± 24.66%, respectively; p = .398) showed no statistically significant difference. In contrast, ACB + ABB biopsies showed higher Musashi-1-positive cells per mm2 compared to ACB + BP biopsies (811.49 ± 875.30 vs. 236.90 ± 280.81; p < .018), where the fusiform cells corresponded mainly with fibroblasts, as demonstrated by ultrastructural analysis. Conclusion Both combinations of materials exhibited bone formation after 6 months of healing in the maxillary sinus cavity. However, the combination with biphasic phycogenic biomaterial induced a higher radiographical vertical resorption and graft collapse in comparison with the combination with anorganic bovine bone, possibly due to a higher remodeling of the graft.

Leer texto completo ↗DOI · 10.1111/clr.13590

Autor Doctor&Cols

Lucía López Chaichío
Rehabilitación Oral y Estética Dental

Cómo citar

Galindo-Moreno P, Padial-Molina M, Lopez-Chaichio L, Gutiérrez-Garrido L, Martín-Morales N, O'Valle F. Algae-derived hydroxyapatite behavior as bone biomaterial in comparison with anorganic bovine bone: A split-mouth clinical, radiological, and histologic randomized study in humans. Clinical Oral Implants Research. 2020. doi:10.1111/clr.13590