Study of serum ctx in 50 oral surgical patients treated with oral bisphosphonates

doi:10.4317/medoral.17583

Q2 · articleImpact Factor · 2.165

AutoresAntonio J Flichy-Fernández, Teresa Alegre-Domingo, Sandra González-Lemonnier, José Balaguer-Martínez, María Peñarrocha-Diago, Yolanda Jiménez-Soriano, David Peñarrocha-Diago, José V Bagán-Sebastián

Por qué importa

Este estudio investiga la posible correlación entre la dosis total de bifosfonatos orales administrados y las variaciones en la concentración sérica de CTX en 50 pacientes sometidos a cirugía oral, incluyendo la colocación de implantes dentales. Se analizaron dos grupos, diferenciados por si se suspendió o no la medicación antes de la extracción de la muestra sanguínea. Los resultados no mostraron una relación significativa entre la dosis total de bifosfonatos (ya sea en miligramos totales o por kilogramo de peso) y los niveles de CTX sérico en ninguno de los grupos. Tampoco se observaron diferencias en el riesgo de osteonecrosis química entre ambos grupos. Estos hallazgos sugieren que, en esta cohorte, la dosis administrada de bifosfonatos orales y la suspensión temporal de la medicación no impactan directamente en las concentraciones de CTX sérico, lo cual es relevante para la planificación de procedimientos quirúrgicos en pacientes que reciben estos fármacos.

Abstract original

Objectives: To determine whether there is a relationship between the total BP dose administered and the variations in serum CTX concentration. Study design: The study included 50 patients requiring dental implant surgery and treated with oral BPs, seen in an Oral Surgery and Implantology Unit between January 2007 and June 2009. The patients were divided into two groups: those in which the medication was not suspended before obtaining the laboratory test sample, and those patients referred from other dental clinics in which BPs was suspended before reporting to our Unit. The total drug dosage administered and the total dose per kilogram body weight were evaluated for comparison with serum CTX. The data obtained were correlated to the osteonecrosis risk table developed by Marx et al. in 2007. Results: There were no significant differences between the two groups in relation to the total administered dose and the dose in mg/kg b.w. Likewise, in both groups no relationship was observed between the serum CTX value and the total administered dose or the dose in mg/kg b.w. No differences were found between the two patient groups regarding chemical osteonecrosis risk based on the criteria of Marx et al. Conclusions: No relationship was observed between the oral BP dose administered (total dose or expressed in mg/kg b.w.) and serum CTX concentration, and suspension of the medication did not influence the serum CTX levels.

Leer texto completo ↗DOI · 10.4317/medoral.17583

Autor Doctor&Cols

Toni Flichy
Cirugía Oral e Implantología

Cómo citar

Flichy-Fernández AJ, Alegre-Domingo T, González-Lemonnier S, Balaguer-Martínez J, Peñarrocha-Diago M, Jiménez-Soriano Y, et al. Study of serum ctx in 50 oral surgical patients treated with oral bisphosphonates. Medicina Oral, Patología Oral y Cirugía Bucal. 2012. doi:10.4317/medoral.17583