Selective Serotonin Reuptake Inhibitors and dental implant failure: A retrospective clinical study

AutoresSalgado-Peralvo AO, et al.

Por qué importa

Este estudio retrospectivo analizó la posible asociación entre el consumo de inhibidores selectivos de la recaptación de serotonina (ISRS) y el fracaso o la supervivencia de implantes dentales. Con una cohorte de 170 pacientes y 573 implantes colocados entre 2014 y 2020, se observó una tasa de fracaso significativamente mayor en pacientes tratados con ISRS (18.31%) en comparación con aquellos no tratados (4.38%). El riesgo de fracaso del implante se multiplicó por 4.53 en pacientes consumidores de estos fármacos, aumentando a 3.70 en análisis multivariante. Asimismo, la tasa de supervivencia a 90 meses fue inferior en el grupo de ISRS (84.30% frente a 96%). Estos hallazgos sugieren una relación entre la ingesta de ISRS y un peor pronóstico en la implantología dental, un aspecto relevante a considerar en la planificación y el seguimiento de tratamientos en pacientes polimedicados.

Abstract original

The trend in recent decades in Europe and the United States points to an exponential increase in the consumption of antidepressant drugs and, in particular, selective serotonin reuptake inhibitors (SSRIs). This retrospective study aimed to investigate whether there is an association between SSRI intake and dental implant (DI) failure or survival and, secondarily, to investigate the influence of other systemic and local factors. This retrospective cohort study was done in accordance with the the STROBE (Strengthening the Reporting of Observational Studies in Epidemiology) guidelines for observational studies. A total of 170 patients received 573 DIs between 2014 and 2020.The reported DI failure rate was 6.11% (n = 35 DIs). Of these 18.31% failed in patients treated with SSRIs while 4.38% failed in patients who were not prescribed SSRIs (p < 0.001). Specifically, use of these drugs was associated with a hazard ratio rate of DI failure that was 4.53 times higher (95% CI: 1.93 to 10.61), and in the multivariate analysis, a 3.70 times higher adjusted risk was found. A lower DI survival rate at 90 months' follow up was also observed in these patients compared with those not taking them (84.30% vs 96%, respectively; p = 0.00014). With the limitations of the present study it can be affirmed that there is a relation between the intake of SSRIs and DI failure, as well as a lower survival rate in these patients.

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Autor Doctor&Cols

Orion Salgado
Rehabilitación Oral y Estética Dental

Cómo citar

Salgado-Peralvo AO, al. E. Selective Serotonin Reuptake Inhibitors and dental implant failure: A retrospective clinical study. Comunicación (póster). 2022.