Efficacy of Pre-Procedural Mouthwashes against SARS-CoV-2: A Systematic Review of Randomized Controlled Trials

doi:10.3390/jcm11061692

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AutoresAlvaro Garcia-Sanchez, Juan‐Francisco Peña‐Cardelles, Steve Ruiz, Flor Robles, Esther Ordonez-Fernandez, Ángel-Orión Salgado-Peralvo, James Balloch, Jacob C. Simon

Por qué importa

La presente revisión sistemática analiza la evidencia disponible sobre la eficacia de los enjuagues bucales como medida para reducir la carga viral de SARS-CoV-2 en saliva. Dado que la mucosa oral es una de las primeras afectadas por el virus y que los procedimientos dentales que generan aerosoles suponen un riesgo de contagio para el profesional, es relevante evaluar el potencial de los colutorios para mitigar esta transmisión. Se incluyeron ensayos controlados aleatorizados que evaluaron el uso de diferentes enjuagues como intervención. Los resultados sugieren que aquellos que contienen PVP-I, CHX y CPC podrían presentar actividad virucida frente a SARS-CoV-2 en saliva, siendo consideradas como coadyuvantes en la reducción del riesgo de infección cruzada en la práctica clínica dental.

Abstract original

The oral mucosa is one of the first sites to be affected by the SARS-CoV-2. For this reason, healthcare providers performing aerosol-generating procedures (AGPs) in the oral cavity are at high risk of infection with COVID-19. The aim of this systematic review is to verify whether there is evidence in the literature describing a decrease in the salivary viral load of SARS-CoV-2 after using different mouthwashes. An electronic search of the MEDLINE database (via PubMed), Web of Science, SCOPUS, and the Cochrane library database was carried out. The criteria used were those described by the PRISMA® Statement. Randomized controlled trial studies that have used mouthwashes as a form of intervention to reduce the viral load in saliva were included. The risk of bias was analyzed using the Joanna Briggs Institute Critical Appraisal Tool. Ultimately, eight articles were included that met the established criteria. Based on the evidence currently available in the literature, PVP-I, CHX and CPC present significant virucidal activity against SARS-CoV-2 in saliva and could be used as pre-procedural mouthwashes to reduce the risk of cross-infection.

Leer texto completo ↗DOI · 10.3390/jcm11061692

Autor Doctor&Cols

Orion Salgado
Rehabilitación Oral y Estética Dental

Cómo citar

Garcia-Sanchez A, Peña‐Cardelles J, Ruiz S, Robles F, Ordonez-Fernandez E, Salgado-Peralvo Á, et al. Efficacy of Pre-Procedural Mouthwashes against SARS-CoV-2: A Systematic Review of Randomized Controlled Trials. Journal of Clinical Medicine. 2022. doi:10.3390/jcm11061692